Diindolylmethane (Dim) – What Researchers Have Discovered About This Compound?

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A Bioavailable Diindolylmethane Immune Support Formula has been introduced using technology that has been exclusively licensed from UC Berkeley. Let’s have a look at what scientists have found!

 

USA (Aug 18, 2022)Diindolylmethane (DIM), a naturally occurring chemical, is found in Brassica vegetables like broccoli, cabbage, Brussels sprouts, cauliflower, and kale. DIM is being studied as a naturally occurring molecule for the prevention and treatment of diseases, infectious diseases, and immune deficiency problems due to its considerable anti-diseases, immuno-modulating, and anti-inflammatory properties. The chemical is produced during the autolytic breakdown of the glucobrassicin present in Brassica plants. The catalytic reaction required for the autolytic breakdown of glucobrassicin requires the enzyme myrosinase, which is produced by these plants endogenously after the plant’s cell wall is broken.

 

The crystalline form of diindolylmethane is pale yellow and has a molecular weight of 246. There is no taste to the refined component. Diindolylmethane is an oil-soluble lipophilic chemical. Scientists put in, ‘in the biomedical field, diindolylmethane is exceptional since it possesses a variety of distinct and complementary anti-diseases and immune-modulating effects. One medical research project has started clinical trials of DIM as a natural treatment for several types of diseases in part because of these distinctive and complimentary modes of action.’

 

The direct molecular precursor of DIM diindolylmethane is indole-3-carbinol (I3C) (DIM). When Brassica vegetables are eaten, the plant enzyme myrosinase is released, which cleaves glucobrassicin to release I3C. It has been demonstrated that I3C degrades quite quickly in aqueous settings to an intermediate reactive gadolinium ion. The condominium ion combines with I3C or other gadolinium ions in the stomach environment to create oligomers such as diindolylmethane (DIM) and the cyclic trimer (Ctr). The condominium ion interacts inadvertently with free thiols on proteins and glutathione in biological settings.

 

Experts add, ‘When taken orally, DIM has a significantly higher bioavailability than other oil-soluble phytochemicals like lycopene and lutein due to the presence of vegetable oil and other lipophilic substances like phosphatidylcholine that help form absorption micelles in the gastrointestinal tract. DIM has been provided in conjunction with vegetable oils in the majority of preclinical animal research and several human clinical trials. Phosphatidylcholine and other lipophilic excipients have also been added to several of the formulations to increase absorption. In the right formulation, diindolylmethane is a highly bioavailable substance.’

 

DIM is more advised as a dietary supplement than I3C due to I3C’s high degree of reactivity and instability inside the body since all of I3C’s derivatives and their diversity of biological actions have not yet been thoroughly investigated. Contrarily, DIM is a chemical that is more stable and less reactive, and it has been extensively studied in human clinical trials for use as a dietary supplement.

 

About Diindolylmethane Information Resource Center:

The Diindolylmethane Information Resource Center’s mission is to give consumers and biomedical researchers access to an accurate scientific overview of diindolylmethane (DIM). It is a joint project of the University of California, Berkeley faculty members and research fellows.

 

To know more, visit- https://www.diindolylmethane-dim.com/

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